Originally appeared in the Fall/Winter 2017 edition of The Rock
Hometown: Honolulu, HI
Major: Chemistry (Biology and Economics minor)
WHITTIER COLLEGE RESEARCH: I, along with Professor of Chemistry Devin Iimoto and research partner Rachel Moran ‘18, are conducing research that involves two enzymes known as Cytochrome P450 (CYP450) 1A1 and 1B1 and a variety of substituted linear triazene molecules. The CYP450 family of enzymes is prevalent in a number of human tissue types where common cancers occur, such as skin, colon, and breast cancers. The goal of this research is to identify potential inhibitors of the CYP450 1A1 and 1B1 enzymes.
As part of this research, our team has synthesized several linear triazene molecules to test their effectiveness as a potential inhibitor of the CYP450 enzymes. In preliminary screenings, we have seen upwards of 80% inhibition by several triazenes. We are very excited with these results, as they show a lot of promise for medicinal applications. This would be a new, innovative approach in treating certain types of cancers. Instead of targeting existing cancerous cells, this research would look into targeting the enzymes responsible for converting healthy cells to cancerous ones.
Our team will present these findings at a conference for undergraduate chemistry research in the spring.
OFF-CAMPUS RESEARCH EXPERIENCE: The Hawaii Pacific Health Summer Student Research Program gave me the opportunity to delve into the intricacies of clinical research, surgical procedures, and the everyday lives of practicing physicians. Over the course of this eight-week program I have grown tremendously as a scholar and as an aspiring physician.
PLANS POST-GRADUATION: Pursue a career in orthopedic surgery.
CO-CURRICULAR ACTIVITIES: Poet Baseball • Nu Mu Rho (chemistry honor society)
